Rocksmith is a guitar simulator game that actually allows one to play with a real guitar, bass guitar, or lead guitar (electric). PlayStation 3, Xbox 360, Microsoft Windows are the platforms upon which you can play the Rocksmith music game.
It's unique from Rock Band as it really has actual application to the real instrument on the game interface! The video below goes more into detail:
My name is Nikki. The preferred method of play for me is PS3. If you are looking to buy Rocksmith Bundle see this Rocksmith Reviews link for a great deal under $40 for a brand new bundle of the Rocksmith game!
Read more about Rocksmith reviews here at Rocksmith Wikipedia.